INVITRO AND INVIVO METHODS TO DEFINE SUNSCREEN PROTECTION

被引：30

作者：

GROVES, GA

AGIN, PP

SAYRE, RM

机构：

[1] Department of Pharmacy, University of Queensland, Brisbane

[2] Department of Photobiology Research, Coppertone Solar Research Center, Schering—Plough. Inc., Memphis, Tennessee, 38151

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 1979年 / 20卷 / 03期

关键词：

D O I：

10.1111/j.1440-0960.1979.tb00217.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The potential ability of nine sunscreen preparations to prevent erythema was assessed by two commonly used in vitro methods—the thin‐film technique and the dilute‐solution method—as well as by a new in vitro method—the hairless mouse procedure. The study indicates that there are serious deficiencies in these first two methods when their results are compared to those obtained from in vivo testing. These two spectrophotometric methods predicted a much higher decree of effectiveness than was obtained under in‐use conditions. The new in vitro method described here that uses the excised epidermis of the hairless mouse gave results comparable to those obtained in human volunteers. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：112 / 119

页数：8

共 6 条

[1] Cumpclik B.M., Analytical Procedures and Evaluation of Sunscreens, J. Soc. Cosmet. Chem., 23, (1972)
[2] Robertson D.F., Groves G.A., The Selection and Use of Topical Sunscreens, Med. J. Aust., 2, (1972)
[3] Sayre R., Agin P.P., Le Vee G.J., Marlow E., A Comparison of the Performance of Six Sunscreen Formulations on Human Skin, Photochem. Photobiol., (1978)
[4] Pines E., A New Technique to Assess Sun‐Screen Effectiveness, J. Soc. Cosmet. Chem., 29, (1978)
[5] (1978)
[6] Von Ham G., Herzog W., Sunscreen—A Study of Present State of Knowledge, Pharm. Internat., 6, (1969)

← 1 →