GLYCOSAMINOGLYCAN METABOLISM OF THE MEDIAL MENISCUS, THE MEDIAL COLLATERAL LIGAMENT AND THE HIP-JOINT CAPSULE IN EXPERIMENTAL OSTEOARTHRITIS CAUSED BY IMMOBILIZATION OF THE RABBIT KNEE

被引：35

作者：

VIDEMAN, T

ERONEN, I

FRIMAN, C

LANGENSKIOLD, A

机构：

[1] ORTHOPAED HOSP INVALID FDN, RES LAB, VANTA, FINLAND

[2] UNIV HELSINKI, CENT HOSP, DEPT MED 4, SF-00290 HELSINKI 29, FINLAND

[3] UNIV HELSINKI, CENT HOSP, DEPT ORTHOPAED & TRAUMATOL, SF-00290 HELSINKI 29, FINLAND

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1979年 / 50卷 / 04期

关键词：

Glycosaminoglycans; Immobilization; Joint capsule; Osteoarthritis;

D O I：

10.3109/17453677908989791

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A study was made of glycosaminoglycan metabolism in experimental osteoarthritis caused by immobilization of the rabbit knee in extension. Samples from the medial meniscus, the medial collateral ligament of the knee and the hip joint capsule were obtained and analysed after 2, 6, 10, 17, 30 and 87 days of immobilization, samples from the mobile limb serving as controls. the tissue concentrations of glycosaminoglycans were determined from measurements of hexosamine and uronic acid after prior papain proteolysis and subsequent purification. the uptake of 31S-sulphate (DPM/ug hexosamine) was used as an indicator of the synthesis rate of sulphated glycosaminoglycans. In both early and advanced immobilization osteoarthritis, the synthesis rate and the content of glycosaminoglycans were increased in all tissues. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：465 / 470

页数：6

共 16 条

[1]

AKESON WH, 1973, CLIN ORTHOP RELAT R, P356

[2] COLLAGEN CROSS-LINKING ALTERATIONS IN JOINT CONTRACTURES - CHANGES IN REDUCIBLE CROSS-LINKS IN PERIARTICULAR CONNECTIVE-TISSUE COLLAGEN AFTER 9 WEEKS OF IMMOBILIZATION [J].