CHRONIC INTRACEREBRAL INFUSIONS OF VASOPRESSIN AND VASOPRESSIN ANTAGONIST MODULATE SOCIAL RECOGNITION IN RAT

被引：41

作者：

BLUTHE, RM

DANTZER, R

机构：

[1] INRA-INSERM U176, Bordeaux, Rue Camille Saint-Saens

来源：

BRAIN RESEARCH | 1992年 / 572卷 / 1-2期

关键词：

VASOPRESSIN; SOCIAL RECOGNITION; MALE RAT; CASTRATION;

D O I：

10.1016/0006-8993(92)90480-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10-mu-g vasopressin (AVP) whereas intact male rats were implanted with a similar device containing 50-mu-g of 1-deaminopenicillamine 2-O-methyltyrosine arginine vasopressin (dPTyr(Me)AVP), a specific antagonist of the vasopressor like receptors of vasopressin. Control rats in each experimental group were implanted with an Accurel device containing water. Castrated rats treated with AVP explored familiar juvenile conspecifics in the same manner as intact male rats. Conversely, intact male rats treated with dPTyr(Me)AVP explored familiar juveniles in the same manner as castrated male rats. These results confirm the role of androgen-dependent vasopressinergic neurotransmission in social recognition.

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收藏

页码：261 / 264

页数：4

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