REGIOSPECIFIC AND ENANTIOSELECTIVE METABOLISM OF 8,9-EPOXYEICOSATRIENOIC ACID BY CYCLOOXYGENASE

被引：38

作者：

ZHANG, JY

PRAKASH, C

YAMASHITA, K

BLAIR, IA

机构：

[1] VANDERBILT UNIV, DEPT CHEM, NASHVILLE, TN 37232 USA

[2] VANDERBILT UNIV, DEPT PHARMACOL, NASHVILLE, TN 37232 USA

[3] VANDERBILT UNIV, CTR MOLEC TOXICOL, NASHVILLE, TN 37232 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91619-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8(S),9(R)-epoxyeicosatrienoic acid, a major product of the renal cortex, was found to be a substrate for cyclooxygenase from human platelets and ram seminal vesicles. 11(R)-hydroxy-8(S),9(R)-epoxyeicosatrienoic acid was the sole metabolic product. The 8(R),9(S)-enantiomer formed both C-11 and C-15 hydroxylated metabolites. These novel findings suggest that the cyclooxygenase-dependent renal vasoconstrictor activity of 8(S),9(R)-epoxyeicosatrienoic acid may be due to the 11(R)-hydroxy metabolite. © 1992.

引用

页码：138 / 143

页数：6

共 28 条

[1] STEREOSPECIFICITY OF THE HYDROXYEICOSATETRAENOIC AND HYDROXYOCTADECADIENOIC ACIDS PRODUCED BY CULTURED BOVINE ENDOTHELIAL-CELLS [J].