INTRAMOLECULAR MICHAEL-ADDITION-INDUCED Z-]E ISOMERIZATION OF HORNER-EMMONS REACTION-PRODUCTS DURING THE SYNTHESIS OF THE N(14)-C(18) SUBUNIT OF CYCLOTHEONAMIDE-A

被引：14

作者：

ROTH, P ^{[1
]}

METTERNICH, R ^{[1
]}

机构：

[1] SANDOZ PHARMA LTD,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 28期

关键词：

D O I：

10.1016/0040-4039(92)88082-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protected N(14) to C(18) amino acid subunit 3 of cyclotheonamide A (1) has been stereoselectively prepared via Horner-Emmons reaction followed by a novel intramolecular Michael-Addition-induced Z --> E isomerization of the alpha,beta-unsaturated carboxylic ester 8.

引用

页码：3993 / 3996

页数：4

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