PROTECTIVE EFFECTS OF ARBAPROSTIL AGAINST INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS - SIGNIFICANCE OF MAINTAINED GASTRIC BLOOD-FLOW

被引:6
作者
TAKANASHI, H
AKIMA, M
机构
[1] Department of Pharmacology, Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd., Shizuoka 412, Komakado, Gotemba
关键词
ARBAPROSTIL; GASTRIC BLOOD FLOW; INDOMETHACIN; GASTRIC LESION; NONRADIOACTIVE MICROSPHERE;
D O I
10.1254/jjp.59.349
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The purpose of the present study was to investigate the relationship between the effects of 15(R)-15-methylprostaglandin E2 (arbaprostil) on gastric blood flow (GBF) and its protective effects on gastric lesions in rats. The GBF of anesthetized rats was measured by two different methods: Total blood flow into the stomach (total GBF) was determined by means of an ultrasonic pulsed Doppler flow meter; and gastric mucosal blood flow (mucosal GBF) was measured by nonradioactive microspheres. Systemic blood pressure (SBP), heart rate (HR) and gastric vascular resistance (GVR) were recorded simultaneously. Arbaprostil (10-100-mu-g/kg) given i.v. did not affect resting total or mucosal GBF even though it decreased SBP and GVR. Significant improvement of the total and mucosal GBF decreased by indomethacin pretreatment (10 mg/kg, i.v.) was observed by administration of arbaprostil (10-100-mu-g/kg, i.v.) in a dose-dependent manner. Furthermore, i.v.-administration of this agent, in the same dose-range, prevented the formation of gastric lesions induced by indomethacin. The present result suggests that mitigation for the ischemic state of the gastric mucosa may be one of the important mechanisms for the prophylactic and curative effect of arbaprostil on gastric lesions induced by indomethacin.
引用
收藏
页码:349 / 355
页数:7
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