Vitrectomy, fluid-gas exchange and transforming growth factor-beta-2 for the treatment of traumatic macular holes

被引：43

作者：

Rubin, JS ^{[1
]}

Glaser, BM ^{[1
]}

Thompson, JT ^{[1
]}

Sjaarda, RN ^{[1
]}

Pappas, SS ^{[1
]}

Murphy, RP ^{[1
]}

机构：

[1] RETINA INST MARYLAND,BALTIMORE,MD 21204

来源：

OPHTHALMOLOGY | 1995年 / 102卷 / 12期

关键词：

D O I：

10.1016/S0161-6420(95)30786-5

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To evaluate whether vitreous surgery is successful in closing full-thickness traumatic macular holes and whether there is subsequent improvement in visual acuity. Methods: Twelve eyes from 12 consecutive patients with traumatic macular holes underwent vitrectomy, fluid-gas exchange and instillation of bovine or recombinant transforming growth factor (TGF)-beta-2. Three of four eyes underwent repeat vitrectomy with TGF-beta-2 after the initial procedure failed to close the macular hole. Results: Eleven (92%) of 12 eyes had closure of the macular hole. Follow-up ranged from 3 to 33 months. Visual acuity improved by 2 or more lines in 8 (67%) of 12 eyes. Six (50%) of 12 eyes improved to 20/40 or better. All 3 eyes that underwent reoperation had successful closure of the macular hole and achieved 2 or more lines of visual improvement. Conclusion: Treatment of full-thickness traumatic macular holes with vitrectomy, fluid-gas exchange, and TGF-beta-2 may result in successful anatomic closure and visual improvement.

引用

页码：1840 / 1845

页数：6

共 18 条

[1]

Aaberg T. M., 1970, SURV OPHTHALMOL, V15, P139

[2] MACULAR HOLES [J].