CLOSE CORRELATION OF THE CARDIOPROTECTIVE EFFECT OF FK409, A SPONTANEOUS NO RELEASER, WITH AN INCREASE IN PLASMA CYCLIC-GMP LEVEL

被引：31

作者：

KITA, Y

SUGIMOTO, T

HIRASAWA, Y

YOSHIDA, K

MAEDA, K

机构：

[1] Department of Pharmacology, New Drug Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, 532, 1-6, Kashima Yodogawa-ku

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1994年 / 113卷 / 01期

关键词：

FK409; ISDN; NITRIC OXIDE; CYCLIC GMP; MYOCARDIAL INFARCTION;

D O I：

10.1111/j.1476-5381.1994.tb16165.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

FK409 ((+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide), which has been reported by us to be a new spontaneous nitric oxide (NO) releaser, prevented myocardial infarction following occlusion and reperfusion in rat coronary artery and increased plasma cyclic GMP level in rats, dose-dependently and significantly at 32 mg kg(-1). Isosorbide dinitrate (ISDN), which is the most popular orally active NO donor used in the treatment of ischaemic cardiovascular diseases, did not show significant effects at 32 mg kg(-1) in either experiment. Therefore, it is suggested that FK409 can attenuate myocardial injury during ischaemia and reperfusion in contrast to ISDN and a change in plasma cyclic GMP level may serve as an indicator of the cardioprotective effect of NO-releasing drugs.

引用

页码：5 / 6

页数：2

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