THE DYNAMIC REGULATION OF INTEGRIN ADHESIVENESS

被引：415

作者：

DIAMOND, MS

SPRINGER, TA

机构：

[1] HARVARD UNIV, SCH MED, CTR BLOOD RES, DEPT PATHOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, COMM CELL & DEV BIOL, BOSTON, MA 02115 USA

来源：

CURRENT BIOLOGY | 1994年 / 4卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-9822(00)00111-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways. © 1994 Elsevier Science Ltd. All rights reserved.

引用

页码：506 / 517

页数：12

共 118 条

[1]

ALTIERI DC, 1991, J IMMUNOL, V147, P1891

[2] OLIGOSPECIFICITY OF THE CELLULAR ADHESION RECEPTOR MAC-1 ENCOMPASSES AN INDUCIBLE RECOGNITION SPECIFICITY FOR FIBRINOGEN [J].