MUSCLE-DERIVED NEUROTROPHIN-4 AS AN ACTIVITY-DEPENDENT TROPHIC SIGNAL FOR ADULT MOTOR-NEURONS

被引：313

作者：

FUNAKOSHI, H

BELLUARDO, N

ARENAS, E

YAMAMOTO, Y

CASABONA, A

PERSSON, H

IBANEZ, CF

机构：

[1] KAROLINSKA INST, DEPT MED BIOCHEM & BIOPHYS, MOLEC NEUROBIOL LAB, S-17177 STOCKHOLM, SWEDEN

[2] KAROLINSKA INST, NOBEL INST NEUROPHYSIOL, S-17177 STOCKHOLM, SWEDEN

[3] KAROLINSKA INST, INST WOMAN & CHILD HLTH, S-17177 STOCKHOLM, SWEDEN

[4] UNIV CATANIA, INST FISIOL HUMANA, CATANIA, ITALY

来源：

SCIENCE | 1995年 / 268卷 / 5216期

关键词：

D O I：

10.1126/science.7770776

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The production of neurotrophin-4 (NT-4) in rat skeletal muscle was found to depend on muscle activity. The amounts of NT-4 messenger RNA present decreased after blockade of neuromuscular transmission with alpha-bungarotoxin and increased during postnatal development and after electrical stimulation in a dose-dependent manner. NT-4 immunoreactivity was detected in slow, type I muscle fibers. Intramuscular administration of NT-4 induced sprouting of intact adult motor nerves. Thus, muscle-derived NT-4 acted as an activity-dependent neurotrophic signal for growth and remodeling of about motor-neuron innervation. NT-4 may thus be partly responsible for the effects of exercise and electrical stimulation on neuromuscular performance.

引用

页码：1495 / 1499

页数：5

共 33 条

[1] Brown M., Holland R., Hopkins W., Annu. Rev. Neurosci., 4, (1981)
[2] Henderson C., Huchet M., Changeux J.-P., Nature, 302, (1983)
[3] Caroni P., Schneider C., Kiefer M.C., Zapf J., J. Cell Biol., 125, (1994)
[4] Funakoshi H., Et al., J. Cell Biol., 123, (1993)
[5] Koliatsos V.E., Clatterbuck R.E., Winslow J.W., Cayouette M.H., Price D.L., Neuron, 10, (1993)
[6] Wernig A., Herrera A., Prog. Neurobiol., 27, (1986)
[7] Wigston D., J. Neurosci., 9, (1989)
[8] Waerhaug O., Anat. Embryol., 185, (1992)
[9] Connor E.A., Smith M.A., J. Neurobiol., 25, (1994)
[10] Czeh G., Gallego R., Kudo N., Kuno M., J. Physiol., 281, (1978)

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