DESIGN AND SYNTHESIS OF A NOVEL EPOXIDE-CONTAINING PYRROLO[2,1-C][1,4]BENZODIAZEPINE (PBD) VIA A NEW CYCLIZATION PROCEDURE

被引：11

作者：

WILSON, SC ^{[1
]}

HOWARD, PW ^{[1
]}

THURSTON, DE ^{[1
]}

机构：

[1] UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DIV MED CHEM,PORTSMOUTH PO1 2DZ,HANTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 35期

关键词：

D O I：

10.1016/0040-4039(95)01224-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a potential DNA-crosslinking pyrrolo[2,1-c][1,4]benzodiazepine (PBD) substituted at the C8-position with a 2,3-epoxypropaneoxy moiety using a new cyclization procedure is described.

引用

页码：6333 / 6336

页数：4

共 12 条

[1]

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[2]

Bose, Thompson, Ching, Berardini, Jenkins, Neidle, Hurley, Thurston, J. Am. Chem. Soc., 114, (1992)

[3]

Bose, Thompson, Smellie, Berardini, Hartley, Jenkins, Neidle, Thurston, Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers, Journal of the Chemical Society, Chemical Communications, (1992)

[4]

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[5]

Confalone, Huie, Ko, Cole, J. Org. Chem., 53, (1988)

[6]

Thurston, Bose, Chem. Rev., 94, (1994)

[7]

Bonini, Righi, Synthesis, 3, (1994)

[8]

Hurley, Reck, Thurston, Langley, Chem. Res. Toxicol., 1, (1988)

[9]

Fukuyama, Liu, Linton, Lin, Nishino, Tetrahedron Lett., 34, (1993)

[10]

Carpino, Han, J. Org. Chem., 37, (1972)

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