SELECTIVE ACTIVATION OF PHOSPHOINOSITIDE HYDROLYSIS BY A RIGID ANALOG OF GLUTAMATE

被引：101

作者：

DESAI, MA ^{[1
]}

CONN, PJ ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT PHARMACOL,ATLANTA,GA 30322

来源：

NEUROSCIENCE LETTERS | 1990年 / 109卷 / 1-2期

关键词：

d,l-1-Amino-1,3-cyclopentanedicar-boxylic acid; Excitatory amino acid; Glutamate; Hippocampus; Ibotenate; Inositol phosphate; Phosphoinositide hydrolysis;

D O I：

10.1016/0304-3940(90)90555-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ibotenate and trans-d,l-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) are rigid analogues of glutamate. Ibotenate has been shown to activate phosphoinositide hydrolysis in rat brain slices. We now report that trans-ACPD also stimulates phosphoinositide hydrolysis but with much higher potency and efficacy than ibotenate. The pharmacological profiles, regional distributions, and developmental regulation of the responses to ibotenate and trans-ACPD are similar, suggesting that these agonists act at the same site. However, trans-ACPD is the first agonist described that is selective for this receptor relative to other excitatory amino acid receptor subtypes. © 1990.

引用

页码：157 / 162

页数：6

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