DO PANIC ATTACKS REFLECT AN ABNORMALITY IN SEROTONIN RECEPTOR SUBTYPES

被引：6

作者：

DENBOER, JA

WESTENBERG, HGM

机构：

[1] Department of Biological Psychiatry, University Hospital Utrecht, Utrecht, 3508 GA, P. O

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1991年 / 6卷

关键词：

5-HT; PANIC DISORDER; ANXIETY; ANTIDEPRESSANTS; 5-HTP; FLUVOXAMINE; CLOMIPRAMINE; MCPP; 5-HT RECEPTOR TYPES;

D O I：

10.1002/hup.470060506

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This chapter reviews and discusses the evidence supporting the role of 5-HT in the mechanism of action of antidepressants in panic disorder (PD). The data were interpreted as compelling evidence in favour of a specific pharmacological effect on symptoms of panic and phobic avoidance. Results from our group provide strong circumstantial evidence as to the role of 5-HT in these effects. In the light of the available data we have advanced the hypothesis that this effect of antidepressants might be mediated through stimulation of the postsynaptic, probably inhibitory, elements of the 5-HT receptor in the septohippocampal area of the brain. Finally, the proposed mechanism of action does not preclude the involvement of other neuronal systems in certain dimensions of the psychopathology of PD.

引用

页码：S25 / S30

页数：6

共 31 条

[1] CLOMIPRAMINE FOR PANIC DISORDER .1. THE 1ST 10 WEEKS OF A LONG-TERM COMPARISON WITH IMIPRAMINE
CASSANO, GB
PETRACCA, A
PERUGI, G
NISITA, C
MUSETTI, L
MENGALI, F
MCNAIR, DM
[J]. JOURNAL OF AFFECTIVE DISORDERS, 1988, 14 (02) : 123 - 127
[2] SEROTONIN FUNCTION IN ANXIETY .2. EFFECTS OF THE SEROTONIN AGONIST MCPP IN PANIC DISORDER PATIENTS AND HEALTHY-SUBJECTS
CHARNEY, DS
WOODS, SW
GOODMAN, WK
HENINGER, GR
[J]. PSYCHOPHARMACOLOGY, 1987, 92 (01) : 14 - 24
[3] SEROTONIN FUNCTION IN PANIC DISORDER - A DOUBLE-BLIND PLACEBO CONTROLLED-STUDY WITH FLUVOXAMINE AND RITANSERIN
DENBOER, JA
WESTENBERG, HGM
[J]. PSYCHOPHARMACOLOGY, 1990, 102 (01) : 85 - 94
[4] BEHAVIORAL, NEUROENDOCRINE, AND BIOCHEMICAL EFFECTS OF 5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PANIC DISORDER
DENBOER, JA
WESTENBERG, HGM
[J]. PSYCHIATRY RESEARCH, 1990, 31 (03) : 267 - 278
[5] EFFECT OF A SEROTONIN AND NORADRENALINE UPTAKE INHIBITOR IN PANIC DISORDER - A DOUBLE-BLIND COMPARATIVE-STUDY WITH FLUVOXAMINE AND MAPROTILINE
DENBOER, JA
WESTENBERG, HGM
[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1988, 3 (01) : 59 - 74
[6] EFFECT OF SEROTONIN UPTAKE INHIBITORS IN ANXIETY DISORDERS - A DOUBLE-BLIND COMPARISON OF CLOMIPRAMINE AND FLUVOXAMINE
DENBOER, JA
WESTENBERG, HGM
KAMERBEEK, WDJ
VERHOEVEN, WMA
KAHN, RS
[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1987, 2 (01) : 21 - 32
[7] DENBOER JA, 1988, THESIS STATE U UTREC
[8] EFFECT OF A SELECTIVE SEROTONIN UPTAKE INHIBITOR IN AGORAPHOBIA WITH PANIC ATTACKS - A DOUBLE-BLIND COMPARISON OF ZIMELDINE, IMIPRAMINE AND PLACEBO
EVANS, L
KENARDY, J
SCHNEIDER, P
HOEY, H
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1986, 73 (01) : 49 - 53
[9] GLOGER S, 1981, AM J PSYCHIAT, V138, P1215
[10] GRUNHAUS L, 1984, J CLIN PSYCHIAT, V45, P25

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