MONOCYTE-MEDIATED ENTRY OF PATHOGENS INTO THE CENTRAL-NERVOUS-SYSTEM

被引：46

作者：

WILLIAMS, AE ^{[1
]}

BLAKEMORE, WF ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT CLIN VET MED, CAMBRIDGE, ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1990年 / 16卷 / 05期

关键词：

encephalitis; Lentivirus; meningitis; microglia; monocytes; pathogenesis; Streptococcus; Trojan horse;

D O I：

10.1111/j.1365-2990.1990.tb01274.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The origin of the microglia has long been a subject of debate. However it is now clear that monocytes enter the normal central nervous system and follow a series of morphological transformations as they differentiate into microglia. Thus, microglia are of monocytic origin. Since monocytes migrate into the normal CNS, they represent potential vehicles for the entry of pathogens into the nervous system and indeed may carry particulate matter into the CNS. Both viruses and bacteria use this ‘Trojan horse’ mechanism of entry in the pathogenesis of CNS disease. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：377 / 392

页数：16

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