DOPAMINERGIC AND LIGAND-INDEPENDENT ACTIVATION OF STEROID-HORMONE RECEPTORS

被引：520

作者：

POWER, RF ^{[1
]}

MANI, SK ^{[1
]}

CODINA, J ^{[1
]}

CONNEELY, OM ^{[1
]}

OMALLEY, BW ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030

来源：

SCIENCE | 1991年 / 254卷 / 5038期

关键词：

D O I：

10.1126/science.1749936

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The current view of how steroid hormone receptors affect gene transcription is that these receptors, on binding ligand, change to a state in which they can interact with chromatin and regulate transcription of target genes. Receptor activation is believed to be dependent only on this ligand-binding event. Selected steroid hormone receptors can be activated in a ligand-independent manner by a membrane receptor agonist, the neurotransmitter dopamine. In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progesterone receptor (cPR) from cytoplasm to nucleus. Dual activation by progesterone and dopamine was dissociable, and a serine residue in the cPR was identified that is not necessary for progesterone-dependent activation of cPR, but is essential for dopamine activation of this receptor.

引用

页码：1636 / 1639

页数：4

共 56 条

[1] THE SIGNIFICANCE OF L-AMINO-ACID DECARBOXYLASE AND DARPP-32 IN THE KIDNEY [J].