GENOTYPING AND ASSOCIATION ANALYSIS OF HLA-B61 IN JAPANESE

被引：13

作者：

LIN, L ^{[1
]}

TOKUNAGA, K ^{[1
]}

OGAWA, A ^{[1
]}

ISHIKAWA, Y ^{[1
]}

KASHIWASE, K ^{[1
]}

AKAZA, T ^{[1
]}

KUWATA, S ^{[1
]}

TADOKORO, K ^{[1
]}

JUJI, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT TRANSFUS MED & IMMUNOHEMATOL,TOKYO 113,JAPAN

来源：

HUMAN IMMUNOLOGY | 1993年 / 37卷 / 02期

关键词：

D O I：

10.1016/0198-8859(93)90147-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The distribution of HLA-B61-related alleles, B*4002-B*4006, was examined in the Japanese population by using PCR-SSO and PCR-RFLP methods. About half of the B61-positive individuals possessed B*4002 and the remaining half possessed B*4006. In addition, these two major B61 alleles were separately associated with different HLA-C alleles: B*4002 exhibited a strong linkage disequilibrium with Cw10, whereas B*4006 was strongly associated with C blank and DR9. Amino acid residues that contribute to the serologic epitopes of the B61 group and their relationships with other HLA-B locus antigens are discussed.

引用

页码：95 / 100

页数：6

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