POLYAMINES MODULATE THE FUNCTION OF TRANSFECTED GLUTAMATE-RECEPTOR MGLUR1A

被引：6

作者：

MANEV, RM ^{[1
]}

GABELLINI, N ^{[1
]}

MANEV, H ^{[1
]}

机构：

[1] FIDIA RES LABS,VIA PONTE DELLA FABBRICA 3A,I-35031 ABANO TERME,ITALY

来源：

NEUROREPORT | 1993年 / 4卷 / 06期

关键词：

METABOTROPIC GLUTAMATE RECEPTOR; MGLUR1; POLYAMINES; 1S,3R-ACPD (1S,3R-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID); PHOSPHOINOSITIDE HYDROLYSIS;

D O I：

10.1097/00001756-199306000-00059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

METABOTROPIC glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in the absence of 1S,3 R-ACPD even at a concentration of 1 mM, but it potentiated the stimulatory action of 1S,3R-ACPD at 10 muM. The modulatory action of spermine was mimicked by spermidine but not by the short polyamine putrescine.

引用

页码：830 / 832

页数：3

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