PLACEBO-CONTROLLED TRIAL OF PAROXETINE IN DEPRESSIVE-ILLNESS

被引：11

作者：

EDWARDS, JG

GOLDIE, A

机构：

[1] Department of Psychiatry, Royal South Hants Hospital, Southampton

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1993年 / 8卷 / 03期

关键词：

PAROXETINE; PLACEBO; DEPRESSIVE ILLNESS;

D O I：

10.1002/hup.470080306

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A randomized double-blind placebo-controlled trial was carried out to assess the effectiveness, tolerance and unwanted effects of paroxetine in the treatment of depressive illness. Forty-one patients referred to a psychiatric unit in a general hospital were included in the study. Treatment lasted for six weeks. The main outcome measures were changes in scores on the Hamilton rating scale for depression and Leeds self-assessment of 'Depression Specific' scale. Statistically significant improvements occurred in both treatment groups, while the end-point differences in scores show significant advantages of paroxetine over placebo.

引用

页码：203 / 209

页数：7

共 24 条

[1] AN EARLY CLINICAL PHASE-II EVALUATION OF PAROXETINE, A NEW POTENT AND SELECTIVE 5HT-UPTAKE INHIBITOR IN PATIENTS WITH DEPRESSIVE-ILLNESS [J].