INDUCTION OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON ADULT PRIMATE RETINAL NEURONS

被引：17

作者：

OMALLEY, MB ^{[1
]}

MACLEISH, PR ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEUROBIOL LAB,NEW YORK,NY 10021

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 43卷 / 1-2期

关键词：

PRIMATE RETINA; TRAUMATIC INJURY; CNS REGENERATION; MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN;

D O I：

10.1016/0165-5728(93)90074-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of class I major histocompatibility complex (MHC) antigens was examined on adult monkey and human retinal cells following injury caused by dissociation. In a panning assay, neurons and glia demonstrated a rapid induction of class I MHC antigens following enzymatic dissociation, and expression was sustained on regenerating neurons as well as on glia in culture. Class I MHC antigen expression was also enhanced following optic nerve crush of monkey eyes in vivo. These results suggest that the functions of class I MHC antigens may be relevant to primate CNS neurons and glia following injury.

引用

页码：45 / 57

页数：13

共 46 条

[1] MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION ON RAT MICROGLIA FOLLOWING EPIDURAL KAINIC ACID LESIONS [J].