NA+-ACTIVATED K+ CHANNELS - A NEW FAMILY OF LARGE-CONDUCTANCE ION CHANNELS

被引:113
作者
DRYER, SE [1 ]
机构
[1] FLORIDA STATE UNIV,DEPT BIOL SCI,TALLAHASSEE,FL 32306
关键词
D O I
10.1016/0166-2236(94)90093-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sodium-activated K+ channels (I(K(Na))) are a class of large-conductance ion channels expressed in several populations of vertebrate neurons, mammalian cardiac myocytes and Xenopus oocytes. These channels are activated by the binding of Na+ to sites located an the cytoplasmic face of the channel. The physiological functions of I(K(Na)) channels have been difficult to ascertain, in part because their activation typically requires Na+ concentrations considerably higher than those that are normally present in the cytosol. However, there is now evidence suggesting that I(K(Na)) can play a role in the regulation of neuronal excitability, the modulation of the action-potential waveform, and the responses of excitable cells to hypoxia and ischemia.
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页码:155 / 160
页数:6
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