INHIBITION OF POST-REPLICATION REPAIR BY ISONICOTINIC-ACID HYDRAZIDE

被引：24

作者：

KLAMERTH, OL

机构：

[1] Institut für Humangenetik der Universität Heidelberg, Heidelberg

来源：

MUTATION RESEARCH | 1978年 / 50卷 / 02期

关键词：

D O I：

10.1016/0027-5107(78)90029-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the presence of the alkylating mutagen N-methyl-N-nitrosourea (MNU), the well-known tuberculostatic isonicotinic acid hydrazide (INH), even in otherwise ineffective doses, depressed cell number and mitotic index in peripheral human lymphocytes and inhibited the post-replication repair process in Chinese hamster cells (CHO). INH had no influence on unscheduled DNA synthesis (cut-and-patch repair), which was negligible in CHO cells under our conditions. © 1978.

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页码：251 / 261

页数：11

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