INHIBITION IN VITRO OF RAT CEREBRAL GLUTAMINE SYNTHETASE BY AN EXOTOXIN FROM PSEUDOMONAS TABACI

被引：4

作者：

LAMAR, C

SINDEN, SL

DURBIN, RD

机构：

[1] The Department of Medicine, University of Wisconsin School of Medicine, the Veterans Administration Hospital, Madison, WI

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 02期

关键词：

D O I：

10.1016/0006-2952(69)90228-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A toxin elaborated by Pseudomonas tabaci, which causes wildfire disease in tobacco, has recently been shown to cause convulsions in mice and rats. Its formula is thought to be lactyl diamino hydroxy pimelic acid. It was shown that the toxin in vitro is a competitive inhibitor of cerebral glutamine synthetase. Preincubation studies with the toxin indicate that it is irreversibly bound to the glutamine synthetase molecule in the presence of ATP and Mg2+. The action of the toxin in vitro on glutamine synthetase resembles in many respects the effects of methionine sulfoximime. © 1969.

引用

页码：521 / &

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