ACTION OF DIAMIDE ON HORMONE STIMULATED LIPOLYSIS IN RAT ADIPOSE-TISSUE

被引：1

作者：

CAPARROTTA, L ^{[1
]}

GAION, RM ^{[1
]}

FASSINA, G ^{[1
]}

SILIPRANDI, N ^{[1
]}

机构：

[1] CNR,CTR STUDIO FISIOL MITOCONDRIALE,I-35100 PADUA,ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1978年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0031-6989(78)80059-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diamide [diazenedicarboxylic acid bis (N,N-dimethylamide)], a thiol oxidizing agent, was able to inhibit noradrenaline and theophylline-stimulated lipolysis in rat adipose tissue. This inhibition was not paralleled by any modification of cAMP level and accumulation. Besides diamide showed a non competitive inhibitory effect (50 per cent) on lipolytic response of adipose tissue to dibutyryl-cAMP. The results provide an indirect but consistent evidence that the observed inhibitory effects could be due to an interaction of diamide at a level subsequent cAMP formation, probably to a modification of protein kinase activity. © 1978 The Italian Pharmacological Society.

引用

页码：21 / 29

页数：9

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