HYBRID MYELOMAS PRODUCING ANTIBODIES AGAINST A HUMAN NEURO-BLASTOMA ANTIGEN PRESENT ON FETAL BRAIN

被引：203

作者：

KENNETT, RH

GILBERT, F

机构：

[1] UNIV PENN,SCH MED,CTR HUMAN GENET CELL,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19104

来源：

SCIENCE | 1979年 / 203卷 / 4385期

关键词：

D O I：

10.1126/science.424740

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spleen cells from mice immunized with a cultured human neuroblastoma were hybridized with the mouse plasmacytoma P3X63Ag8. Hybrid myelomas were screened for production of antibodies that reacted with human neuroblastomas but not with cells from other tissues. One of these hybridoma antibodies reacted with an antigen present on the six human neuroblastomas tested, one of two retinoblastomas, a glioblastoma, and fetal brain, but did not react with other tumors or tissues including adult human brain. Copyright © 1979 AAAS.

引用

页码：1120 / 1121

页数：2

共 13 条

[1] DOUBLE MINUTE CHROMOSOMES AND HOMOGENEOUSLY STAINING REGIONS IN CHROMOSOMES OF A HUMAN NEUROBLASTOMA CELL LINE [J].