HEPATOTROPIN MESSENGER-RNA EXPRESSION IN HUMAN FETAL LIVER DEVELOPMENT AND IN LIVER-REGENERATION

被引：90

作者：

SELDEN, C

JONES, M

WADE, D

HODGSON, H

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT VIROL,LONDON W12 0HS,ENGLAND

[2] ROYAL POSTGRAD MED SCH,MRC,LIPOPROT TEAM,LONDON W12 0HS,ENGLAND

来源：

FEBS LETTERS | 1990年 / 270卷 / 1-2期

关键词：

Fetal development; Liver; Messenger RNA; Regeneration;

D O I：

10.1016/0014-5793(90)81239-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 569 bp probe against the β-chain of hepatotropin was used to examine expression of RNA for this growth factor in human adult and foetal liver, foetal kidney and pancreas, and rat liver after partial hepatectomy. Low level expression of a 6kb RNA occurred in human adult and normal rat liver. 70% hepatectomy increased expression, peaking at 10 h and returning to near normal levels 24 h after resection. The 6 kb band was strongly expressed in human foetal liver, as compared with adult, but not in foetal kidney or pancreas, suggesting a major role for hepatotropin in both foetal development and regeneration of the liver. © 1990.

引用

页码：81 / 84

页数：4

共 17 条

[1] REGULATION OF TGF-BETA GENE-EXPRESSION IN RAT-LIVER INTOXICATED WITH CARBON-TETRACHLORIDE [J].