SYNTHESIS OF SPIROKETALS - A GENERAL-APPROACH

被引：23

作者：

CRIMMINS, MT

OMAHONY, R

机构：

[1] Department of Chemistry, University of North Carolina, North Carolina 27599-3290, Chapel Hill

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 23期

关键词：

D O I：

10.1021/jo00310a023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general procedure for the synthesis of functionalized spiroketals from lactones is described. Addition of the lithium acetylide of cis-1-methoxy-1-buten-3-yne to lactones followed by a hydration of the acetylene, hydrolysis of the enol ether and cyclization gives excellent yields of spiroketals containing a useful enone functionality. © 1990, American Chemical Society. All rights reserved.

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页码：5894 / 5900

页数：7

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