COHERENT FIBER OPTIC SENSOR FOR EARLY DETECTION OF CATARACTOGENESIS IN A HUMAN EYE LENS

被引:19
作者
DHADWAL, HS
ANSARI, RR
DELLAVECCHIA, MA
机构
[1] NASA, LEWIS RES CTR, CWRU, CLEVELAND, OH 44135 USA
[2] WILLS EYE HOSP & RES INST, PHILADELPHIA, PA 19107 USA
关键词
BIOMEDICAL OPTICS; HUMAN LENS FIBERS; LIGHT SCATTERING; FIBER OPTIC SENSORS; CATARACTS; PROTEIN AGGREGATES;
D O I
10.1117/12.60741
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
A lensless backscatter fiber optic probe is used to measure the size distribution of protein molecules inside an excised, but intact, human eye lens. The fiber optic probe, about 5 mm in diameter, can be positioned arbitrarily close to the anterior surface of the eye; it is a transreceiver, which delivers a Gaussian laser beam into a small region inside the lens and provides a coherent detection of the laser light scattered by the protein molecules in the backward direction. Protein sizes determined from the fast and slow diffusion coefficients show good correlation with the age of the lens and cataractogenesis.
引用
收藏
页码:233 / 238
页数:6
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