INVIVO ANGIOGENESIS BY PLATELET-DERIVED WOUND-HEALING FORMULA IN INJURED SPINAL-CORD

被引：8

作者：

HIRAIZUMI, Y

TRANSFELDT, EE

KAWAHARA, N

SUNG, JH

KNIGHTON, D

FIEGEL, VD

机构：

[1] UNIV MINNESOTA,DEPT ORTHOPAED SURG,420 DELAWARE ST SE,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DEPT NEUROPATHOL,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,DEPT SURG,MINNEAPOLIS,MN 55455

来源：

BRAIN RESEARCH BULLETIN | 1993年 / 30卷 / 3-4期

关键词：

ANGIOGENESIS; PLATELET-DERIVED WOUND-HEALING FORMULA; SPINAL CORD INJURY;

D O I：

10.1016/0361-9230(93)90264-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vivo angiogenesis was investigated using platelet-derived wound-healing formula (PDWHF) in the injured cat spinal cord. Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks. Selection of PDWHF-Hydron or Hydron was double blinded. The PDWHF-Hydron group showed notable neovascularization as well as dilation around the injury site, and this was statistically significant when compared to the control group. PDWHF seems to play a role in the healing processes of spinal cord injury and may have important interactions with other growth factors and in particular neurogenic growth factor.

引用

页码：353 / 357

页数：5

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