NITRIC OXIDE-RELEASING COMPOUNDS INHIBIT DICTYOSTELIUM-DISCOIDEUM AGGREGATION WITHOUT ALTERING CGMP PRODUCTION

被引：20

作者：

TAO, YP

HOWLETT, A

KLEIN, C

机构：

[1] ST LOUIS UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOL,1402 S GRAND BLVD,ST LOUIS,MO 63104

[2] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL & PHYSIOL SCI,ST LOUIS,MO 63104

来源：

FEBS LETTERS | 1992年 / 314卷 / 01期

关键词：

DICTYOSTELIUM-DISCOIDEUM; NITRIC OXIDE; AGGREGATION; GUANYLYL CYCLASE;

D O I：

10.1016/0014-5793(92)81459-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of nitric oxide-releasing compounds on Dictyostelium discoideum cell development and guanylyl cyclase activity were studied. The addition of SNP (sodium nitroprusside) or SIN-1 (3-morpholino-syndnonimine) to starved cells inhibited their differentiation and aggregation in a concentration-dependent manner. In contrast to mammalian systems, SNP did not significantly affect guanylyl cyclase activity in cell lysates of D. discoideum, nor did it stimulate cGMP production in intact cells. The results suggest that the inhibitory effects of NO on D. discoideum cell aggregation are through a mechanism independent of an effect on guanylyl cyclase activity.

引用

页码：49 / 52

页数：4

共 19 条

[1] DYNAMICS OF ANTIGENIC MEMBRANE SITES RELATING TO CELL AGGREGATION IN DICTYOSTELIUM-DISCOIDEUM [J].