QUINOLONE ARTHROPATHY - ACUTE TOXICITY TO IMMATURE ARTICULAR-CARTILAGE

被引：88

作者：

GOUGH, AW

KASALI, OB

SIGLER, RE

BARAGI, V

机构：

[1] Department of Pathology and Experimental Toxicology, Warner-Lambert Company

[2] Department of Immunopathology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor

来源：

TOXICOLOGIC PATHOLOGY | 1992年 / 20卷 / 03期

关键词：

DOG; ARTICULAR CARTILAGE INJURY; XENOBIOTIC INDUCED ARTHROPATHY; QUINOLONE ANTIBACTERIALS; CHONDROCYTES; CARTILAGE MATRIX; PROTEOGLYCANS;

D O I：

10.1177/019262339202000313

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A class effect of quinolone antibacterial agents observed during animal toxicity testing is a specific arthropathy (QAP). Despite the growing list of laboratory animals susceptible to QAP and reports of arthralgia in patients treated with quinolones, the potential for QAP development in humans remains unknown. This review discusses current concepts in the biology of articular cartilage and how these concepts elucidate QAP pathogenesis. Biomechanical forces within synovial joints and toxicokinetic properties of quinolones contribute to QAP induction. Since a limited number of mechanistic pathways exist for acute articular damage, QAP may serve as a research tool to probe the pathobiology of injury to articular cartilage.

引用

页码：436 / 449

页数：14

共 111 条

[1] Adam D., Use of quinolones in pediatric patients, Rev. Infect. Dis, II, pp. S1113-S1116, (1989)
[2] Alfaham M., Holt M.E., Goodchild M.C., Arthropathy in a patient with cystic fibrosis taking ciprofloxacin, Br. Med. J, 295, (1987)
[3] Amacher D.E., Schomaker S.J., Gootz T.D., McGuirk P.R., Proteoglycan and procollagen syntheses in rat embryo limb bud cultures treated with quinolone antibacterials, pp. 307-312, (1989)
[4] Anonymous, Chondromalacia patellae, Lancet, 1, pp. 558-559, (1985)
[5] Ayedelotte M.B., Greenhill R.R., Kuettner K.E., Differences between subpopulations of cultured bovine articular chondrocytes. II, Proteoglycan metabolism. Connect. Tissue Res, 18, pp. 233-234, (1988)
[6] Ayedelotte M.B., Kuettner K.E., Differences between subpopulations of cultured bovine articular chondrocytes, Connect. Tissue Res, 18, pp. 205-222, (1988)
[7] Azzo W., Woessner J.F., Purification and characterization of an acid metalloproteinase from human articular cartilage, J. Biol. Chem, 261, pp. 5434-5441, (1986)
[8] Bailey R.R., Kirk J.A., Peddie B.A., Norfloxacin-induced rheumatic disease. N, Z. Med, 96, (1983)
[9] Bailey R.R., Natale R., Linton A.L., Nalidixic acid arthralgia, Can. Med. Assoc. J, 107, pp. 604-607, (1972)
[10] Baker J.R., Caterson B., Christner J.E., The link proteins of cartilage proteoglycan aggregates: Structure and function. Ala, J. Med. Sci, 18, pp. 46-51, (1981)

← 1 2 3 4 5 6 7 8 9 10 →