SIGNAL-TRANSDUCTION IN TRYPANOSOMA-CRUZI - OPPOSITE EFFECTS OF ADENYLCYCLASE AND PHOSPHOLIPASE-C SYSTEMS IN GROWTH-CONTROL

被引：22

作者：

OLIVEIRA, MM

ROCHA, ED

RONDINELLI, E

ARNHOLDT, AV

SCHARFSTEIN, J

机构：

[1] Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, de Janeiro

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1993年 / 124卷 / 02期

关键词：

SIGNAL TRANSDUCTION; TRYPANOSOMA-CRUZI GROWTH CONTROL; PHOSPHOLIPID METABOLISM; INOSITOL PHOSPHATES; DIACYLGLYCEROL-PHOSPHOLIPASE-C;

D O I：

10.1007/BF00929200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fetal calf serum (FCS), which is mitogenic for the pathogenic protozoa T. cruzi, inhibits cAMP production in basal and forskolin-stimulated epimastigotes. It also activates phosphoinositides hydrolysis yielding diacylglycerol and inositol phosphates (Ins-P). Ins-P production is enhanced by AlF4-, GTP or beta-gamma-methylene-GTP, thus implying G proteins mediation in the phenomenon. An enzyme with phospholipase C activity which may be involved in the phospholipid metabolism was partially characterized.

引用

页码：91 / 99

页数：9

共 29 条

[1] DEVELOPMENTALLY REGULATED, PHOSPHOLIPASE-C MEDIATED RELEASE OF THE MAJOR SURFACE GLYCOPROTEIN OF AMASTIGOTES OF TRYPANOSOMA-CRUZI [J].

ANDREWS, NW ;

ROBBINS, ES ;

LEY, V ;

HONG, KS ;

NUSSENZWEIG, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (02) :300-314

[2]

BERRIDGE MJ, 1987, ANNU REV BIOCHEM, V56, P159, DOI 10.1146/annurev.bi.56.070187.001111

[3] CHANGES IN THE LEVELS OF INOSITOL PHOSPHATES AFTER AGONIST-DEPENDENT HYDROLYSIS OF MEMBRANE PHOSPHOINOSITIDES [J].

BERRIDGE, MJ ;

DAWSON, RMC ;

DOWNES, CP ;

HESLOP, JP ;

IRVINE, RF .

BIOCHEMICAL JOURNAL, 1983, 212 (02) :473-482

[4]

CamargO E. P., 1964, Revista do Instituto de Medicina Tropical de Sao Paulo, V6, P93

[5] A GLYCAN-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE-D IN HUMAN-SERUM [J].

DAVITZ, MA ;

HERELD, D ;

SHAK, S ;

KRAKOW, J ;

ENGLUND, PT ;

NUSSENZWEIG, V .

SCIENCE, 1987, 238 (4823) :81-84

[6] TRYPANOSOMA-CRUZI - ADRENERGIC MODULATION OF CYCLIC-AMP ROLE IN PROLIFERATION AND DIFFERENTIATION OF AMASTIGOTES INVITRO [J].

DECASTRO, SL ;

MEIRELLES, MDL ;

OLIVEIRA, MM .

EXPERIMENTAL PARASITOLOGY, 1987, 64 (03) :368-375

[7] RADIOLIGAND BINDING CHARACTERIZATION OF BETA-ADRENERGIC RECEPTORS IN THE PROTOZOA TRYPANOSOMA-CRUZI [J].

DECASTRO, SL ;

OLIVEIRA, MM .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 1987, 87 (01) :5-8

[8] THE INOSITOL PHOSPHATE DIACYLGLYCEROL SIGNALING PATHWAY IN TRYPANOSOMA-CRUZI [J].

DOCAMPO, R ;

PIGNATARO, OP .

BIOCHEMICAL JOURNAL, 1991, 275 :407-411

[9] PROTEIN KINASE-C IN TRYPANOSOMA-CRUZI EPIMASTIGOTE FORMS - PARTIAL-PURIFICATION AND CHARACTERIZATION [J].

GOMEZ, ML ;

ERIJMAN, L ;

ARAUZO, S ;

TORRES, HN ;

TELLEZINON, MT .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 36 (02) :101-108

[10] CYCLIC-AMP AND ADENYLATE-CYCLASE ACTIVATORS STIMULATE TRYPANOSOMA-CRUZI DIFFERENTIATION [J].

GONZALESPERDOMO, M ;

ROMERO, P ;

GOLDENBERG, S .

EXPERIMENTAL PARASITOLOGY, 1988, 66 (02) :205-212

← 1 2 3 →