BLOCKADE OF ETHANOL DISCRIMINATION BY ISRADIPINE

被引：15

作者：

COLOMBO, G ^{[1
]}

AGABIO, R ^{[1
]}

LOBINA, C ^{[1
]}

REALI, R ^{[1
]}

FADDA, F ^{[1
]}

GESSA, GL ^{[1
]}

机构：

[1] UNIV CAGLIARI,INST HUMAN PHYSIOL,I-09124 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 265卷 / 03期

关键词：

ETHANOL; ISRADIPINE; L-TYPE CA2+ CHANNEL; DRUG DISCRIMINATION; (RAT);

D O I：

10.1016/0014-2999(94)90427-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of the dihydropyridine Ca2+ channel antagonist, isradipine, on ethanol discrimination was-assessed in rats trained to discriminate 1.5 g/kg ethanol from water in a T-maze, food-reinforced drug discrimination procedure. Pretreatment with isradipine (0, 1.0, 3.0 and 5.0 mg/kg i.p.) resulted in a dose-dependent blockade of ethanol discrimination. The results of the present study suggest that L-type Ca2+ channels are involved in the mediation of ethanol discriminative stimulus effects.

引用

页码：167 / 170

页数：4

共 15 条

[1]

CZARNECKA E, 1993, ALCOHOL ALCOHOLISM, V28, P649

[2] ISRADIPINE AND OTHER CALCIUM-CHANNEL ANTAGONISTS ATTENUATE ETHANOL-CONSUMPTION IN ETHANOL-PREFERRING RATS [J].

FADDA, F ;

GARAU, B ;

COLOMBO, G ;

GESSA, GL .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (03) :449-452

[3]

GRANT KA, 1993, ADV BIOMEDICAL ALCOH, P445

[4] BAY K-8644 POTENTIATES THE ANXIOLYTIC EFFECT OF ETHANOL [J].

KIRAC, R ;

EROGLU, L .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 39 (02) :325-327

[5] EFFECTS OF THE CALCIUM-ANTAGONIST ISRADIPINE ON COCAINE INTRAVENOUS SELF-ADMINISTRATION IN RATS [J].

MARTELLOTTA, MC ;

KUZMIN, A ;

MUGLIA, P ;

GESSA, GL ;

FRATTA, W .

PSYCHOPHARMACOLOGY, 1994, 113 (3-4) :378-380

[6] A FUNCTIONAL CORRELATE FOR THE DIHYDROPYRIDINE BINDING-SITE IN RAT-BRAIN [J].

MIDDLEMISS, DN ;

SPEDDING, M .

NATURE, 1985, 314 (6006) :94-96

[7] THE CALCIUM-CHANNEL ACTIVATOR, BAY K 8644, ENHANCES K+-EVOKED EFFLUX OF ACETYLCHOLINE AND NORADRENALINE FROM RAT-BRAIN SLICES [J].

MIDDLEMISS, DN .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1985, 331 (01) :114-116

[8] PSYCHOPHARMACOLOGICAL PROPERTIES OF CALCIUM-CHANNEL INHIBITORS [J].

PUCILOWSKI, O .

PSYCHOPHARMACOLOGY, 1992, 109 (1-2) :12-29

[9] DIFFERENT EFFECT OF DILTIAZEM AND NIFEDIPINE ON SOME CENTRAL ACTIONS OF ETHANOL IN THE RAT [J].

PUCILOWSKI, O ;

KRZASCIK, P ;

TRZASKOWSKA, E ;

KOSTOWSKI, W .

ALCOHOL, 1989, 6 (02) :165-168

[10] EFFECT OF CALCIUM-CHANNEL BLOCKERS ON ALCOHOL-CONSUMPTION IN ALCOHOL-DRINKING MONKEYS [J].

REZVANI, AH ;

GRADY, DR ;

JANOWSKY, DS .

ALCOHOL AND ALCOHOLISM, 1991, 26 (02) :161-167

← 1 2 →