PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF NITRIC-OXIDE

被引：44

作者：

STEWART, AG

PHAN, LH

GRIGORIADIS, G

机构：

[1] Microsurgery Research Centre, St. Vincent's Hospital, Fitzroy, Victoria

来源：

MICROSURGERY | 1994年 / 15卷 / 10期

关键词：

D O I：

10.1002/micr.1920151006

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Nitric oxide (NO), identified as the biochemical messenger of endothelial-dependent relaxation, is of obvious chemical simplicity, but the range and complexity of its biological actions are only now emerging. NO is an important determinant of vascular resistance, it reduces thrombogenicity of the vascular endothelium, contributes to non-specific, host-defence mechanisms, and is a neurotransmitter in the peripheral and central nervous systems. In addition to these physiological roles, there is now convincing evidence that excessive, prolonged production of NO contributes to tissue damage in septicemia, ischemia/reperfusion injury, and other inflammatory conditions. (C) 1994 Wiley-Liss, Inc.

引用

页码：693 / 702

页数：10

共 116 条

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