ABSOLUTE-CONFIGURATION OF MAIN-CHAIN OF AAL-TOXINS

被引：27

作者：

OIKAWA, H ^{[1
]}

MATSUDA, I ^{[1
]}

KAGAWA, T ^{[1
]}

ICHIHARA, A ^{[1
]}

KOHMOTO, K ^{[1
]}

机构：

[1] TOTTORI UNIV,FAC AGR,PLANT PATHOL LAB,TOTTORI 680,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 47期

关键词：

AAL-TOXIN; ALTERNARIA ALTERNATA; ABSOLUTE CONFIGURATION;

D O I：

10.1016/S0040-4020(01)89343-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

AAL-toxins TA(1) 1 and TA(2) 2, host-specific toxins produced by Alternaria alternata, were degraded to 2-methylbutanol, 3-methylnonan-1,9-diol and N-protected 4-aminobutan-1-3-diol, which were further converted to (R)-MTPA esters. These esters were correlated with synthesis samples by comparison of their 500 MHz H-1-NMR spectra. The remaining stereocenters were determined by the comparison of H-1-NMR spectra of 6a and 7 derived from 1 and 2 with those of synthetic model compounds. These data conclude that AAL-toxins possess 2S, 4S, 5R, 11S, 13S, 14R and 15R configurations.

引用

页码：13347 / 13368

页数：22

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