IN-VIVO STUDIES ON EFFECT OF TRENIMON .I. CHANGES OF BIOCHEMICAL EVENTS AND INHIBITION OF CELL PROLIFERATION OF EHRLICH ASCITES TUMOR CELLS

被引：15

作者：

LISS, E

PALME, G

OEFF, K

机构：

[1] Nuklearmedizinische Abteilung der Medizinischen Kliniken der Freien Universität Berlin, Berlin

来源：

ZEITSCHRIFT FUR KREBSFORSCHUNG | 1968年 / 71卷 / 01期

关键词：

D O I：

10.1007/BF00524507

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

After application of Trenimon to tumor-bearing mice alterations of some biochemical parameters were investigated. Incorporation of H3-thymidine into DNA proved more sensitive than incorporation of H3-cytidine into RNA, incorporation of C14-leucine into protein, and content of DPN. After application of doses just sufficient to inhibit cell proliferation, inhibition of H3-thymidine incorporation was observed some hours after application of Trenimon; the percentage of DNA synthesizing cells did not decrease. The results suggest, that the treated cells continue synthesizing DNA - at a lower rate - after having finished the normal doubling of DNA. © 1968 Springer-Verlag.

引用

页码：89 / &

共 27 条

[1]

BIERLING R, 1964, Z Krebsforsch, V66, P362, DOI 10.1007/BF00524166

[2] ALTERATIONS IN CELLULAR METABOLISM ASSOCIATED WITH CELL DEATH INDUCED BY URACIL MUSTARD AND 6-THIOGUANINE [J].