COMPARATIVE BIOASSAY OF DRUGS IN ADJUVANT-INDUCED ARTHRITIS IN RATS - FLUFENAMIC ACID, MEFENAMIC ACID, AND PHENYLBUTAZONE

被引：87

作者：

WINDER, CV

LEMBKE, LA

STEPHENS, MD

机构：

[1] Department of Experimental Therapeutics, Division of Medical and Scientific Affairs, Parke, Davis & Company, Ann Arbor, Michigan

[2] Department of Experimental Therapeutics, Division of Medical and Scientific Affairs, Company, Ann Arbor, Michigan

[3] Department of Experimental Therapeutics, Division of Medical and Scientific Affairs, Company, Ann Arbor, Michigan

[4] Iowa, Iowa, 52240

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 05期

关键词：

D O I：

10.1002/art.1780120503

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

By injecting adjuvant into the tail rather than paw, valid bioassays were achieved in terms of paw volume and body growth after preventive treatment for 18 days, treatment of the established disease for 6 weeks, and 6 weeks after termination of 6 weeks of therapy. By these six criteria, and with doses of the fenamates (per kilogram) equivalent to human dosage, flufenamate was 2.6 to 5.6 and mefenamate 0.35 to 1.8 times as potent as phenylbutazone. Copyright © 1969 American College of Rheumatology

引用

页码：472 / &

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