THERAPEUTIC EFFECT OF CIMETIDINE IN PATIENTS UNDERGOING HEMODIALYSIS

被引：18

作者：

JONES, RH

LEWIN, MR

PARSONS, V

机构：

[1] ULWICH HOSP,LONDON SE22,ENGLAND

[2] UNIV COLL HOSP LONDON,SCH MED,SURG UNIT,LONDON WC1E 6JJ,ENGLAND

来源：

BRITISH MEDICAL JOURNAL | 1979年 / 1卷 / 6164期

关键词：

D O I：

10.1136/bmj.1.6164.650

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood concentrations of cimetidine were measured and the therapeutic effect of the drug assessed in patients undergoing maintenance haemodialysis. Thirteen patients were given a single oral 200-mg dose of cimetidine a mean of 2–7 hours before the start of dialysis. Dialysing for 6-12-6 mhours led to a mean fall of 71% in blood cimetidine concentration during haemodialysis. Nine patients with various upper gastrointestinal lesions diagnosed endoscopically were treated for up to six weeks with a reduced cimetidine dose of 200 mg 12-hourly; two patients received two courses of treatment. Repeat endoscopy after treatment disclosed satisfactory healin?. and the drus did not accumulate. This lower dose regimen is recommended for patients receiving dialysis who develop upper gastrointestinal lesions for which a histamine H2-receptor antagonist is indicated. © 1979, British Medical Journal Publishing Group. All rights reserved.

引用

页码：650 / 652

页数：3

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