PHARMACOLOGICAL ACTIONS OF HS-6, AN OXIME, ON THE NEUROMUSCULAR-JUNCTION

被引:32
作者
CLEMENT, JG
机构
[1] Biomedical Section, Defence Research Establishment Suffield, Ralston
关键词
Carbachol; Choline uptake; Hemicholinium-like; HS-6; Neuromuscular; Oxime;
D O I
10.1016/0014-2999(79)90158-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of HS-6 [1-(2-hydroxyiminomethylpyridinium)-1-(3-carboxamidopyridinium)-dimethyl ether] on neuromuscular (NM) transmission was investigated using chick biventer cervicis (CBC), rat diaphragm (RD) and guinea pig ileum longitudinal muscle strip (GPLS) preparations. In the CBC preparation HS-6 did not cause a contraction, whereas it produced a dose-related contraction of the GPLS preparation. HS-6 produced a hemicholinium- like NM blockade in the CBC and RD preparations. This was supported by the fact that HS-6 inhibited choline uptake in erythroctes. HS-6 inhibited the contractions of various nicotinic agonists in the CBC preparation and augmented the acetylcholine contractions. The latter was due to AChE inhibition produced by HS-6. © 1979.
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页码:135 / 141
页数:7
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