EMBRYONIC MOTONEURONS GRAFTED INTO THE ADULT CNS CAN DIFFERENTIATE AND MIGRATE

被引：19

作者：

DEMIERRE, B

MARTINOU, JC

KATO, AC

机构：

[1] CTR MED UNIV GENEVA,DEPT PHARMACOL,CH-1211 GENEVA 4,SWITZERLAND

[2] UNIV GENEVA,HOP CANTONAL,DEPT NEUROSURG,CH-1211 GENEVA 4,SWITZERLAND

[3] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,F-31055 TOULOUSE,FRANCE

来源：

BRAIN RESEARCH | 1990年 / 510卷 / 02期

关键词：

Brain graft; Carbiocyanine; Grafted motoneuron; Migration of grafted motoneuron; Spinal cord graft;

D O I：

10.1016/0006-8993(90)91391-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Embryonic mouse motoneurons were labelled by retrograde transport with a fluorescent dye (diI), partially purified on a densdity gradient and grafted into adult mouse CNS for a maximum of 10 weeks. In both the spinal cord and striatum, a small number of fluorescently labelled motoneurons were found to survive as judged by their round, bright appearance and also to differentiate as assessed by their ability to extend neurites. The motoneurons travelled long distances in the spinal cord (2 mm) and in the brain (4 mm) in both white and gray matter. © 1990.

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页码：355 / 359

页数：5

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