CYTOGENETICS OF A RENAL-CELL CARCINOMA IN A 17-MONTH-OLD CHILD - EVIDENCE FOR XP11.2 AS A RECURRING BREAKPOINT

被引：87

作者：

TOMLINSON, GE

NISEN, PD

TIMMONS, CF

SCHNEIDER, NR

机构：

[1] Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX

[2] Department of Pathology, University of Texas Southwestern Medical Center at Dallas, TX

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 01期

关键词：

D O I：

10.1016/0165-4608(91)90184-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.

引用

页码：11 / 17

页数：7

共 42 条

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