ANTI-DEPRESSANTS SELECTIVELY ANTAGONIZE THE HYPERACTIVITY INDUCED IN RATS BY LONG-TERM ISOLATION

被引：79

作者：

GARZON, J

FUENTES, JA

DELRIO, J

机构：

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 3-4期

关键词：

Animal model of depression; Antidepressants; Locomotor activity; Social deprivation;

D O I：

10.1016/0014-2999(79)90293-0

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Rats isolated at 16-18 days of age showed after 10-12 months a complex behavioural syndrome in which locomotor activity was markedly increased when compared to that of group-housed controls. The hyperactivity of the socially deprived animals was selectively blocked by clinically effective antidepressants but not by other classes of psychotropic drugs. The present animal model may be of value for the detection of new antidepressants and contribute to elucidate the aetiology of depression. © 1979.

引用

页码：293 / 296

页数：4

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