EFFECT OF IONIZING-RADIATION ON 15-HYDROXY PROSTAGLANDIN DEHYDROGENASE (PGDH) ACTIVITY IN TISSUES

被引:14
作者
WALKER, DI
EISEN, V
机构
[1] Department of Rheumatology Research, The Middlesex Hospital Medical School, London, W1P 9PG, England
关键词
D O I
10.1080/09553007914551181
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Whole body irradiation of mice with 200-1000 R of unfiltered X-radiation (230 kV, 15mA, 140 R/min) produced extensive falls of 15-hydroxy prostaglandin dehydrogenase (PGDH) activity in the spleen within 4 hours. A transient recovery between 4 and 72 hours was followed by a second reduction in PGDH levels which was still evident 7 days after exposure. In the jejunum and kidney, the falls were smaller. High doses (1000 R) increased PGDH activity in the lung. Effects of radiation on other cellular enzymes, including other dehydrogenases in the cytosol, were less pronounced, and in some cases the opposite of the effects on PGDH. The loss of PGDH may contribute to the increase in prostaglandin concentrations in the spleen and jejunum, and thereby to some features in radiation sickness. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:399 / 407
页数:9
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