THE HLA-DR-BETA-16 ALLOGENOTYPE CONSTITUTES A RISK FACTOR FOR HYPERTROPHIC SCARRING

被引：25

作者：

CASTAGNOLI, C

PERUCCIO, D

STELLA, M

MAGLIACANI, G

MAZZOLA, G

AMOROSO, A

RICHIARDI, P

机构：

[1] UNIV TURIN,DIPARTIMENTO GENET BIOL & CHIM MED,SEZ GENET,I-10124 TURIN,ITALY

[2] CNR,CTR IMMUNOGENET & ISTOCOMPATIBIL,TURIN,ITALY

[3] CTO,DIV CHIRURG PLAST,TURIN,ITALY

[4] CTO,CTR GRANDI USTIONATI,TURIN,ITALY

来源：

HUMAN IMMUNOLOGY | 1990年 / 29卷 / 03期

关键词：

D O I：

10.1016/0198-8859(90)90117-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nineteen patients that had developed hypertrophic scars subsequent to thermal injury were hyped for HLA class II allogenotypes with the restriction fragment length polymorphism technique. A significant association was found with DRβ16 (pc = 1.45 × 10-4; relative risk = 12.25. This finding adds evidence to other data suggesting that immunologic phenomena are involved in pathologic scarring. Moreover, the results presented here have allowed an identification of a genetically determined risk factor for hypertrophic scar formation located in the HLA region. © 1990.

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页码：229 / 232

页数：4

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