THE ROLE OF COMPENSATION ANALYSIS IN THE STUDY OF WETTABILITY, SOLUBILITY, DISINTEGRATION AND DISSOLUTION

In the past, considerable effort has been devoted to understanding the processes of wettability, solubility and disintegration, and their respective roles in the dissolution of solid oral drug delivery systems. In this study, data from the literature that relate to each of these physical processes are considered in terms of compensation analysis. Compensation analysis is a method by which relationships between different samples, and outliners from an otherwise common trend can be investigated. The correct approach to the calculation of thermodynamic parameters, in order to avoid false correlations that are simply artifacts of the calculation method, is discussed. Compensation can be a valuable tool by which physicochemical effects can be studied, and thus is of value to aid the explanation of complex drug release studies.