REGULATORY FUNCTIONS OF PROTEIN-KINASE-C IN GLOMERULAR MESANGIAL CELLS

被引：19

作者：

PFEILSCHIFTER, J

机构：

[1] Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., Basel

来源：

KLINISCHE WOCHENSCHRIFT | 1990年 / 68卷 / 22期

关键词：

Mesangial cells; Phosphatidylcholine; Phosphoinositide; Phospholipase C; Phospholipase D; Prostaglandin; Protein kinase C;

D O I：

10.1007/BF01798064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function. © 1990 Springer-Verlag.

引用

页码：1134 / 1137

页数：4

共 23 条

[1] CALCIUM DEPENDENCY OF PROSTAGLANDIN-E2 PRODUCTION IN RAT GLOMERULAR MESANGIAL CELLS - EVIDENCE THAT PROTEIN KINASE-C MODULATES THE CA-2+-DEPENDENT ACTIVATION OF PHOSPHOLIPASE-A2 [J].