THE INTERACTION OF D-PROPRANOLOL AND DIMYRISTOYL PHOSPHATIDYLCHOLINE LARGE UNILAMELLAR VESICLES INVESTIGATED BY QUASI-ELASTIC LIGHT-SCATTERING AND FOURIER-TRANSFORM INFRARED-SPECTROSCOPY

被引：17

作者：

CAO, A ^{[1
]}

HANTZBRACHET, E ^{[1
]}

AZIZE, B ^{[1
]}

TAILLANDIER, E ^{[1
]}

PERRET, G ^{[1
]}

机构：

[1] UNIV PARIS 13, UFR MED & BIOL HUMAINE, PHARMACOL CLIN & EXPTL LAB, F-93012 BOBIGNY, FRANCE

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1991年 / 58卷 / 03期

关键词：

DIMYRISTOYLPHOPHATIDYLCHOLINE; DMPC; MODEL MEMBRANE; PROPRANOLOL; LOCAL ANESTHETICS; PHASE TRANSITION; QUASI-ELASTIC LIGHT SCATTERING; FT-IR SPECTROSCOPY; INTERDIGITATION;

D O I：

10.1016/0009-3084(91)90096-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of D-propranolol on dimyristoylphosphatidylcholine large unilamellar vesicles has been investigated by quasielastic light scattering and Fourier transform infrared spectroscopy. The results indicate that the drug interacts with the phosphate groups of the polar heads, shifts the phase transition point and alters the low temperature phase. A second transition has been observed, and the new phase of the vesicles induced by the presence of the drug might be an interdigitated one.

引用

页码：225 / 232

页数：8

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