STRUCTURAL ELUCIDATION OF MINOR COMPONENTS OF PEPTIDYL ANTIBIOTIC P168S (LEUCINOSTATINS) BY TANDEM MASS-SPECTROMETRY

被引：23

作者：

ISOGAI, A ^{[1
]}

NAKAYAMA, J ^{[1
]}

TAKAYAMA, S ^{[1
]}

KUSAI, A ^{[1
]}

SUZUKI, A ^{[1
]}

机构：

[1] JEOL LTD, TOKYO 197, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1992年 / 56卷 / 07期

关键词：

D O I：

10.1271/bbb.56.1079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tandem mass spectrometry with a four-sector type mass spectrometer was used to elucidate the structures of minor components of the peptidyl antibiotic P168s (leucinostatins). As N-terminal fragments, ions by B-type cleavage were dominant, while V-type cleavages were observed along with X, Y, and Z types as C-terminal ions. The V-type ions were predominant in the cleavages of the amino terminals of leucyl and hydroxyleucyl residues. The structures of several minor components could be deduced from the tandem mass spectra.

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页码：1079 / 1085

页数：7

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