PROCERAGENIN, AN ANTIBACTERIAL CARDENOLIDE FROM CALOTROPIS-PROCERA

被引：43

作者：

AKHTAR, N

MALIK, A

ALI, SN

KAZMI, SU

机构：

[1] UNIV KARACHI,HEJ RES INST CHEM,KARACHI 75270,PAKISTAN

[2] UNIV KARACHI,IIDRL,DEPT MICROBIOL,KARACHI 75270,PAKISTAN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 08期

关键词：

CALOTROPIS-PROCERA; ASCLEPIADACEAE; CARDENOLIDE; PROCERAGENIN; ANTIBACTERIAL ACTIVITY;

D O I：

10.1016/0031-9422(92)83639-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new cardenolide, proceragenin, has been isolated from Calotropis procera. Its structure was determined as 7-beta,14-beta-dihydroxy-5-alpha-card-20(22)-enolide through spectroscopic studies including 2D NMR and NOE difference measurement. Its biological screening showed antibacterial activity against both Gram positive and Gram negative bacteria.

引用

页码：2821 / 2824

页数：4

共 15 条

[1]

ALLEN JL, 1978, J PEDIATR, V9, P69

[2]

ARDENNE MV, 1964, HELV CHIM ACTA, V47, P1032

[3] C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY [J].

BLUNT, JW ;

STOTHERS, JB .

ORGANIC MAGNETIC RESONANCE, 1977, 9 (08) :439-464

[4]

BUDZIKIEWICZ H, 1964, STRUCTURE ELUCIDATIO, V2, P106

[5]

CARRON R, 1987, Plantes Medicinales et Phytotherapie, V21, P195

[6] CARDENOLIDE ANALOGS .12. C-13 NMR OF SEMI-SYNTHETIC GLYCOSIDES AND SIDE-CHAIN MODIFIED GENINS [J].

CHEUNG, HTA ;

BROWN, L ;

BOUTAGY, J ;

THOMAS, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (06) :1773-1778

[7]

DYMOCK W, 1883, PHARM INDICA, V3, P270

[8]

GEORGE RW, 1972, BIOCH APPLICATION MA, P282

[9]

Hesse G, 1941, LIEBIGS ANN CHEM, V546, P233

[10]

KEDDE DL, 1947, PHARM TIJDS CHR BELG, P169

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