CONFORMATIONALLY RESTRICTED INHIBITORS OF THE HIGH-AFFINITY L-GLUTAMATE TRANSPORTER

被引：57

作者：

BRIDGES, RJ ^{[1
]}

LOVERING, FE ^{[1
]}

HUMPHREY, JM ^{[1
]}

STANLEY, MS ^{[1
]}

BLAKELY, TN ^{[1
]}

CRISTOFARO, MF ^{[1
]}

CHAMBERLIN, AR ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80103-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of acidic amino acids has been prepared and evaluated in an effort to identify the structural features required for binding to and inhibiting the high affinity uptake system that clears L-glutamate from the synaptic cleft during excitatory amino acid-mediated neurotransmission in the mammalian CNS.

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页码：115 / &

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