NUCLEOTIDE-SEQUENCE ANALYSIS OF VARIOLA VIRUS HINDIII-M-GENOME, L-GENOME, I-GENOME FRAGMENTS

被引：37

作者：

SHCHELKUNOV, SN ^{[1
]}

BLINOV, VM ^{[1
]}

TOTMENIN, AV ^{[1
]}

MARENNIKOVA, SS ^{[1
]}

KOLYKHALOV, AA ^{[1
]}

FROLOV, IV ^{[1
]}

CHIZHIKOV, VE ^{[1
]}

GYTOROV, VV ^{[1
]}

GASHIKOV, PV ^{[1
]}

BELANOV, EF ^{[1
]}

BELAVIN, PA ^{[1
]}

RESENCHUK, SM ^{[1
]}

ANDZHAPARIDZE, OG ^{[1
]}

SANDAKHCHIEV, LS ^{[1
]}

机构：

[1] ACAD MED SCI RUSSIA,INST VIRAL PREPARAT,MOSCOW 109088,RUSSIA

来源：

VIRUS RESEARCH | 1993年 / 27卷 / 01期

关键词：

ORTHOPOXVIRUS; VARIOLA VIRUS; SEQUENCE ANALYSIS;

D O I：

10.1016/0168-1702(93)90110-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA of the variola major virus strain India-1967 in the region of HindIII M, L, I fragments has been sequenced. Analysis of this sequence of 18029 bp revealed 19 potential open reading frames (ORFs). Four proposed proteins (L2R, H9R, L5L, L6R) contain metal-binding domains. Comparison of the variola virus (VAR) and vaccinia virus strain Copenhagen (COP) sequences show that the main differences are between proteins L1R and I5R. L1R contains 6 additional amino acid residues on the C-terminus. The protein I5R of VAR contains three Ca2+ binding domains but this COP has deletions in 2 of the 3 established domains. Possible functions of the predicted viral polypeptides are discussed.

引用

页码：25 / 35

页数：11

共 34 条

[1]

BAIROCH A, 1989, PROSITE DICT PROTEIN

[2] COMPARISON OF A CONSERVED REGION IN FOWLPOX VIRUS AND VACCINIA VIRUS GENOMES AND THE TRANSLOCATION OF THE FOWLPOX VIRUS THYMIDINE KINASE GENE [J].

BINNS, MM ;

TOMLEY, FM ;

CAMPBELL, J ;

BOURSNELL, MEG .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :1275-1283

[3] HOMOLOGY BETWEEN RNA-POLYMERASES OF POXVIRUSES, PROKARYOTES, AND EUKARYOTES - NUCLEOTIDE-SEQUENCE AND TRANSCRIPTIONAL ANALYSIS OF VACCINIA VIRUS GENES ENCODING 147-KDA AND 22-KDA SUBUNITS [J].

BROYLES, SS ;

MOSS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) :3141-3145

[4]

Chertov OYu, 1991, Biomed Sci, V2, P151

[5]

CHIKAEV N A, 1991, Molekulyarnaya Biologiya (Moscow), V25, P1533

[6] NUCLEOTIDE-SEQUENCE COMPARISON OF HOMOLOGOUS GENOMIC REGIONS FROM VARIOLA, MONKEYPOX, AND VACCINIA VIRUSES [J].

COWLEY, R ;

GREENAWAY, PJ .

JOURNAL OF MEDICAL VIROLOGY, 1990, 31 (04) :267-271

[7] ANALYSIS OF MEMBRANE AND SURFACE PROTEIN SEQUENCES WITH THE HYDROPHOBIC MOMENT PLOT [J].

EISENBERG, D ;

SCHWARZ, E ;

KOMAROMY, M ;

WALL, R .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 179 (01) :125-142

[8] NUCLEOTIDE-SEQUENCE OF THE THYMIDINE KINASE GENE REGION OF MONKEYPOX AND VARIOLA VIRUSES [J].

ESPOSITO, JJ ;

KNIGHT, JC .

VIROLOGY, 1984, 135 (02) :561-567

[9] ORTHOPOXVIRUS DNA - A COMPARISON OF RESTRICTION PROFILES AND MAPS [J].

ESPOSITO, JJ ;

KNIGHT, JC .

VIROLOGY, 1985, 143 (01) :230-251

[10] PHYSICOCHEMICAL PROPERTIES OF CLONED NUCLEOCAPSID PROTEIN FROM HIV - INTERACTIONS WITH METAL-IONS [J].

FITZGERALD, DW ;

COLEMAN, JE .

BIOCHEMISTRY, 1991, 30 (21) :5195-5201

← 1 2 3 4 →